Glossary // Glossary term Empirical

Prefrontal cortex in emotion regulation

The front part of the frontal lobes, whose lateral, medial and orbital subregions are associated with goal maintenance, cognitive control and valuation. A meta-analysis of 48 neuroimaging studies found that cognitive reappraisal consistently engaged dorsolateral and ventrolateral prefrontal, parietal and lateral temporal regions and was accompanied by modulation of bilateral amygdala activity. These are group-level associations from imaging tasks; they describe regions involved in instructed regulation, not a switch that turns emotions off.

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Studies behind it

The works the definition rests on, with the level of evidence each was appraised at.

  • Buhle, J. T., Silvers, J. A., Wager, T. D., Lopez, R., Onyemekwu, C., Kober, H., Weber, J., & Ochsner, K. N. (2014). Cognitive reappraisal of emotion: A meta-analysis of human neuroimaging studies. doi:10.1093/cercor/bht154

    Level A Meta-analysis

    Supports the claim that reappraisal consistently engaged cognitive control regions and lateral temporal cortex and was accompanied by modulation of bilateral amygdala activity. Group-level activation in instructed laboratory tasks; it does not show how regulation unfolds for an individual in daily life.

  • Ochsner, K. N., & Gross, J. J. (2005). The cognitive control of emotion. doi:10.1016/j.tics.2005.03.010

    Level D Review

    Supports the claim that reappraisal and attentional control involve interactions between prefrontal and cingulate control systems and emotion-generative regions. Narrative review of early imaging work.