Studies // Cited work
Stress and the individual: Mechanisms leading to disease
McEwen, B. S., & Stellar, E. (1993). Stress and the individual: Mechanisms leading to disease.
Level D Review doi:10.1001/archinte.1993.00410180039004
What this study supports
Supports the claim that allostatic load was defined as the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine responses. A conceptual review, not a systematic synthesis.
- Who was studied
- Human and animal studies and selected reviews identified through MEDLINE.
- Design
- Review
- Level of evidence
- Cross-sectional, observational, qualitative work and narrative reviews.
Claims that rest on it
Each claim states what the site asserts, at what strength, and with what caveat.
TheoreticalLevel DConfidence HIGH
Allostasis, a term introduced by Sterling and Eyer, describes physiological regulation that anticipates demands and changes set points rather than holding them constant; allostatic load names the cumulative cost of repeated or chronic activation.
- Scope
- The concepts as defined by their originators.
- Caveat
- The definitions are theoretical and their contrast with homeostasis is disputed.
Last reviewed · Review due · allostasis-predictive-regulation