Studies // Cited work

Stress and the individual: Mechanisms leading to disease

McEwen, B. S., & Stellar, E. (1993). Stress and the individual: Mechanisms leading to disease.

Level D Review doi:10.1001/archinte.1993.00410180039004

What this study supports

Supports the claim that allostatic load was defined as the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine responses. A conceptual review, not a systematic synthesis.

Who was studied
Human and animal studies and selected reviews identified through MEDLINE.
Design
Review
Level of evidence
Cross-sectional, observational, qualitative work and narrative reviews.

Claims that rest on it

Each claim states what the site asserts, at what strength, and with what caveat.

TheoreticalLevel DConfidence HIGH

Allostasis, a term introduced by Sterling and Eyer, describes physiological regulation that anticipates demands and changes set points rather than holding them constant; allostatic load names the cumulative cost of repeated or chronic activation.

Scope
The concepts as defined by their originators.
Caveat
The definitions are theoretical and their contrast with homeostasis is disputed.

Last reviewed · Review due · allostasis-predictive-regulation