Studies // Cited work
Protective and damaging effects of stress mediators
McEwen, B. S. (1998). Protective and damaging effects of stress mediators.
Level D Review doi:10.1056/NEJM199801153380307
What this study supports
Supports the claim that stress mediators protect acutely and contribute to damage when chronically activated or poorly terminated. An influential conceptual review; the allostatic load construct remains debated in measurement.
- Who was studied
- Not applicable: a narrative review of stress mediators and allostatic load.
- Design
- Review
- Level of evidence
- Cross-sectional, observational, qualitative work and narrative reviews.
Claims that rest on it
Each claim states what the site asserts, at what strength, and with what caveat.
TheoreticalLevel DConfidence MODERATE
Relief changes how a state feels and resolution changes the conditions that produce it; relief has value of its own but, taken together with reinforcement, acute mood effects and memory biases, it can be repeated without the underlying difficulty changing.
- Scope
- The project's central argument, synthesised from separate lines of research.
- Caveat
- No study cited here tested the full loop directly; the argument is a synthesis and could be wrong for particular people or activities.
Last reviewed · Review due · relief-not-resolution-thesis
EmpiricalLevel DConfidence HIGH
Stress mediators such as cortisol and catecholamines are protective in the short term but contribute to allostatic load when chronically activated or poorly terminated.
- Scope
- Human stress physiology as summarised in a narrative review.
- Caveat
- Allostatic load is a construct whose measurement is still debated, and the review predates much later work.
Last reviewed · Review due · allostatic-load
TheoreticalLevel DConfidence MODERATE
Allostatic load has been described as the cumulative cost of stress responses that are activated too often or not terminated efficiently, which implies that load can build up when challenges recur faster than recovery.
- Scope
- A conceptual framework, illustrated with arbitrary units in the allostatic-load model.
- Caveat
- The measurement of allostatic load is debated, and the model's linear input and proportional recovery are simplifications with no physiological calibration.
Last reviewed · Review due · allostatic-load-accumulation-model
TheoreticalLevel DConfidence HIGH
Allostasis, a term introduced by Sterling and Eyer, describes physiological regulation that anticipates demands and changes set points rather than holding them constant; allostatic load names the cumulative cost of repeated or chronic activation.
- Scope
- The concepts as defined by their originators.
- Caveat
- The definitions are theoretical and their contrast with homeostasis is disputed.
Last reviewed · Review due · allostasis-predictive-regulation